Cord Blood

Treatable Diseases

What are the types of diseases and conditions that can be treated with Cord Blood Stem Cells and its potential applications?

Stem cells are at the forefront of one of the most fascinating and revolutionary areas of medicine today. Doctors recognise that stem cells have the potential to help treat numerous diseases by generating healthy new cells and tissue.

As a parent, you want to protect your family. At your baby’s birth, you have the unique opportunity to safeguard the health of the ones you love by storing his/her precious cord blood stem cells.

Stem cells in your baby’s cord blood have the potential to be used in the treatment of many diseases today. Stem cells could be used to treat haematopoietic and genetic disorders. In a cord blood transplant, stem cells are infused into a patient’s bloodstream where they go to work - healing and repairing damaged cells and tissue. Upon successful engraftment of the stem cells, the patient’s blood and immune system are regenerated.

There are a wide range of diseases that are treatable with stem cells derived from cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood, including stem cell disorders, acute and chronic forms of leukaemia, myeloproliferative disorders, and many more.

In addition to the host of conditions that can now be treated, it is the potential of stem cell treatments that holds the most excitement as research continues to uncover new possibilities. The potential and efficacy of treating diseases with stem cells are real.


Diseases Treated with Stem Cells

The following is a list of some of the diseases that have been treated with cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood. Stem cell therapies continue to change and evolve quickly.

Blood Cancers

Leukaemia

  • Acute Biphenotypic Leukaemia
  • Acute Lymphoblastic Leukaemia
  • Acute Myelogenous Leukaemia
  • Acute Undifferentiated Leukaemia
  • Chronic Myelogenous Leukaemia
  • Chronic Lymphocytic Leukaemia
  • Juvenile Myelomonocytic Leukaemia
  • Juvenile Chronic Myelogenous Leukaemia

Myeloproliferative Neoplasms

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia
  • Essential Thrombocythemia
  • Polycythemia Vera

Myelodysplastic Syndromes

  • Refractory Anaemia
  • Refractory Anaemia with Excess Blasts
  • Refractory Anaemia with Excess Blasts in Transformation
  • Refractory Anaemia with Ringed Sideroblasts (Sideroblastic Anaemia)
  • Chronic Myelomonocytic Leukaemia

Other Blood Cancers

  • Multiple Myeloma
  • Plasma Cell Leukaemia
  • Waldenstrom’s Macroglobulinemia
  • Histiocytic Neoplasms

Solid Tumors

Tumors

  • Hodgkin Lymphoma
  • Langerhans' Cell Histiocytosis
  • Neuroblastoma
  • Non Hodgkin Lymphoma (Burkitt’s Lymphoma)
  • Retinoblastoma
  • Medulloblastoma
  • Wilms Tumor

Metabolic Disorders

Leukodystrophy Disorders

  • Adrenoleukodystrophy
  • Krabbe Disease (Globoid Cell Leukodystrophy)
  • Metachromatic leukodystrophy
  • Pelizaeus-Merzbacher Disease

Lysosomal Storage Diseases

  • Alpha Mannosidosis
  • Gaucher’s Disease
  • Niemann Pick Disease
  • Sandhoff Disease
  • Wolman Disease

Mucopolysaccharidosis (MPS) Storage Diseases

  • Hunter Syndrome
  • Hurler Syndrome
  • Maroteaux Lamy Syndrome
  • Mucolipidosis II (I-cell Disease)
  • Morquio Syndrome
  • Sanfilippo Syndrome
  • Scheie Syndrome
  • Sly Syndrome (beta glucuronidase deficiency)

Other Metabolic Disorders

Other Metabolic Disorders

  • Lesch–Nyhan Syndrome
  • Osteopetrosis
  • Hermansky-Pudlak Syndrome
Non Malignant Blood Disorders

Anaemias (Deficiences or malformations of red cells)

  • Aplastic Anaemia
  • Congenital Dyserythropoietic Anaemia
  • Fanconi’s Anaemia
  • Paroxysmal Nocturnal Hemoglobinuria

Hereditary Bone Marrow Failure Syndromes

  • Diamond Blackfan Syndrome
  • Dyskeratosis Congenita
  • Pearson’s Syndrome
  • Shwachman Diamond Syndrome

Inherited Red Cell Abnormalities

  • Pure Red Cell Aplasia
  • Sickle Cell Anaemia
  • Beta Thalassemia Major/Cooley’s Anaemia

Inherited Platelet Abnormalities

  • Congenital Amegakaryocytosis Thrombocytopenia
  • Glanzmann’s Thrombasthenia

Immune Disorders

Severe Combined Immune Deficiency (SCID)

  • Bare Lymphocyte Syndrome
  • Omenn Syndrome
  • Reticular Dysgenesis
  • Neutrophil Actin Deficiency
  • SCID with Adenosine Deaminase Deficiency (ADA SCID)
  • SCID which is X linked
  • SCID with absence of T & B Cells
  • SCID with absence of T Cells, Normal B Cells

Neutropenias

  • Kostmann Syndrome (Infantile Genetic Agranulocytosis)
  • Myelokathexis

Phagocyte Disorders

  • Chediak Higashi Syndrome
  • Chronic Granulomatous Disease

Inherited Disorders of the Immune System & other Organs

  • Cartilage Hair Hypoplasia
  • Gunther’s Disease (Congenital Erythropoietic Protoporphyria)
  • Systemic Mastocytosis

Other Inherited Immune System Disorders

  • Common Variable
  • Immunodeficiency
  • DiGeorge Syndrome
  • Evans Syndrome
  • Hemophagocytic
  • Lymphohistiocytosis
  • IKK Gamma Deficiency (NEMO Deficiency)
  • IPEX Syndrome
  • Leukocyte Adhesion Deficiency
  • Wiskott Aldrich Syndrome
  • X linked Lymphoproliferative Disease (Duncan’s Syndrome)
  • X linked Hyper IgM Syndrom
  • Ataxia-Telangiectasia

Banking cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. Use will be ultimately determined by the treating physician.

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